单婵，青岛大学，转化医学研究院，讲师

邮箱：shanchan@mail2.sysu.edu.cn；shanchan2019@163.com

教育与科研经历

2007.09-2011.06  兰州大学，药学院，大学本科

2011.09-2016.06  中山大学，药学院，硕博连读

2016.09至今     青岛大学，转化医学研究院，青年卓越人才/讲师

研究方向

1. 基于非编码核酸及互作蛋白的疾病生物学机制研究

2. 疾病新靶标发现及干预药物学研究

主持科研项目情况

1. c-myc转录调控宫颈鳞癌干细胞特性的分子机制及化学干预策略研究，国家自然科学基金青年项目，25万元。

2. NM23-H2调控宫颈鳞癌干细胞基因转录及干性的分子机制研究，山东省自然科学基金博士项目，10万元。

3. circRNA-S调控胃癌线粒体自噬的作用机制及抗胃癌策略研究，山东省自然科学基金面上项目，10万元。

4. 环状RNA调控的线粒体稳态在胃癌中的作用机制研究，中国博士后面上项目，5万元。

5. circRNA调控的铁死亡在肺癌中的功能机制及基因治疗策略研究，青岛市博士后应用项目，5万元。

6. 环状RNA circPPT通过OCT1/DUSP4信号轴调控胃癌，烟台大学分子药理和药物评价教育部重点实验室开放资助项目，5万元。

7. 青岛大学科研启动经费，5万元。

代表性论著

1. The Crosstalk between Autophagy and Nrf2 Signaling in Cancer: from Biology to Clinical Applications. International Journal of Biological Sciences. 2024; 20(15): 6181-6206.

2. Mesenchymal Stem Cell-Derived Extracellular Vesicles in Cancer Therapy Resistance: from Biology to Clinical Opportunity. International Journal of Biological Sciences. 2024, 20(1): 347-366.

3. Autophagy-induced intracellular signaling fractional nano-drug system for synergistic anti-tumor therapy, Journal of Colloid and Interface Science, 2023, 645: 986-996.

4. Noncoding RNAs in Cancer Ferroptosis: from Biology to Clinical Opportunity. Biomedicine & Pharmacotherapy. 2023, 165:115053.

5. Smart Multistage “Trojan Horse”-Inspired Bovine Serum Albumin-Coated Liposomes for Enhancing Tumor Penetration and Antitumor Efficacy, Biomacromolecules, 2022, 23(12): 5202-5212.

6. Long noncoding RNA NONMMUT015745 inhibits doxorubicin-mediated cardiomyocyte apoptosis by regulating Rab2A-p53 axis. Cell Death Discovery. 2022, 8(1):364.

7. Emerging function and clinical significance of extracellular vesicle noncoding RNAs in lung cancer. Molecular Therapy-oncolytics. 2022, 24:814-833.

8. The Emerging Roles of Autophagy-Related MicroRNAs in Cancer. International Journal of Biological Sciences. 2021, 17(1): 134-150.

9. Biogenesis, functions and clinical significance of circRNAs in gastric cancer. Molecular Cancer. 2019, 18(1): 136.

10. Design, synthesis, and evaluation of isaindigotone derivatives to downregulate c-myc transcription via disrupting the interaction of NM23-H2 with G-quadruplex. Journal of Medicinal Chemistry. 2017, 60(4):1292-1308.

11. Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule. Nucleic Acids Research. 2015, 43(14): 6677-6691.

12. Natural products and their derivatives as G-quadruplex binding ligands. Science China Chemistry. 2013, 56(10): 1351-1363.