赵吉成 男 博士 教授

出生日期：1980.11.27

研究方向：表观遗传调控

电子邮箱（Email）：zzjjcchh@163.com

电话（Tel）13811049767

简历&研究工作摘要

学习及工作简历

1999.9-2006.6 哈尔滨医科大学 基础医学七年制专业 医学学士

2004.9-2006.6 哈尔滨医科大学 基础医学院 神经生物 医学硕士

2006.9-2010.1 北京协和医学院 基础医学研究所 生化系 理学博士

2010.7-2013.6 中国科学院生物物理研究所 博士后

2013.7-2013.12 中国科学院生物物理研究所 助理研究员

2014.1-2022.12中国科学院生物物理研究所 副研究员

2023.1-2024,07 中国科学院生物物理研究所 研究员

2024.08至今 青岛大学

研究工作介绍

本人长期从事表观遗传调控机制的研究，重要关注以下三方面：1）基因差异表达和细胞命运决定的表观遗传调控机制；2）细胞周期间表观遗传记忆的分子机制；3）表观基因组异常改变在疾病发生/发展中的致病作用。目前在Mol Cell，Nat Cell Biol，Nat Commun，Nat Struct & Mol Biol，Gene & Dev等国际权威学术期刊发表论文16篇（其中第一/并列第一作者论文9篇，共被他引400余次）。作为课题负责人主持国家自然科学基金项目3项；作为主要课题骨干参与国家重点研发计划项目1项；同时还参与了国家自然科学基金重点项目、中国科学院战略性先导专项（A类和B类）等课题的研究。

主持/参与科研项目：

1.国家自然科学基金面上项目，32270614，“组蛋白变体H3.3调控异染色质形成的分子机制及其生物学功能”，2023/01-2026/12，54万，在研，主持。

2.国家自然科学基金面上项目，32070604，“多梳抑制复合物介导表观遗传记忆的分子机制及其生物学功能”，2021/01-2024/12，58万，在研，主持。

3.国家重点研发计划，2019YFA0508903，细胞记忆产生和维持的表观遗传机制项目-蛋白质机器与生命过程调控专项子课题“细胞记忆维持的表观遗传机制”，2020/01-2024/12，111.92万，结题，项目骨干。

4.国家自然科学基金青年科学基金项目，31400657，uH2A在染色质高级结构及基因表达调控中的生物学功能研究，2015/01-2017/12，24万元，已结题，主持。

代表论文：( ^#共第一作者，*共通讯作者)

（第一/共第一作者、通讯/共通讯作者8篇）

1.Jicheng Zhao^#, Jie Lan^#, Min Wang^#, Cuifang Liu^#, Zheng Fang, Aoqun Song, Tiantian Zhang, Liang Wang, Bing Zhu, Ping Chen*, Juan yu*, Guohong Li*. H2AK119ub1 differentially fine-tunes gene expression by modulating canonical-PRC1 and H1-dependent chromatin compaction. Mol Cell, 2024, 84(1):1191-1205. (IF: 16.0)

2.Aoqun Song^#, Yunting Wang^#, Cuifang Liu, Juan Yu, Zixu Zhang, Liting Lan, Haiyan Lin, Jicheng Zhao*, Guohong Li*. Replication-coupled inheritance of chromatin states. Cell Insight, 2024, 3(6):100195.

3. Cuifang Liu^#, Juan Yu^#, Aoqun Song^#, Min Wang, Jiansen Hu, Ping Chen, Jicheng Zhao*，Guohong Li*. Histone H1 facilitates restoration of H3K27me3 during DNA replication by chromatin compaction. Nature Communications, 2023, 14(1):4081. (IF: 16.6)

4.Yi-Zhou Wang^#; Cuifang Liu^#; Jicheng Zhao^#; Juan Yu; Anfeng Luo; Xue Xiao; Shuo-Xing Dou; Lu Ma; Peng-Ye Wang; Ming Li; Guohong Li; Jianbin Yan; Ping Chen*; Wei Li*. H2A mono-ubiquitination differentiates FACT`s functions in nucleosome assembly and disassembly. Nucleic Acids Research, 2022, 50(2): 833-846. (IF: 19.160)

5.Jicheng Zhao^#, Min Wang^#, Luyuan Chang, Juan Yu, Aoqun Song, Cuifang Liu, Wenjun Huang, Tiantian Zhang, Xudong Wu, Xiaohua Shen, Bing Zhu, Guohong Li*. RYBP/YAF2-PRC1 Complexes and Histone H1-dependent Chromatin Compaction Mediate Propagation of H2AK119ub1 during Cell Division. Nature Cell Biology, 2020, 22(4), 439-452. (IF: 20.042)

6.Xiaoping Liang^#, Shan Shan^#, Lu Pan^#, Jicheng Zhao^#, Anand Ranjan, Feng Wang, Zhuqiang Zhang, Yingzi Huang, Hanqiao Feng, Debbie Wei, Li Huang, Xuehui Liu, Qiang Zhong, Jizhong Lou, Guohong Li, Carl Wu*, and Zheng Zhou*. Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1. Nature Structural & Molecular Biology, 2016, 23(4):317-23. (IF: 16.8)

7.Ping Chen^#, Jicheng Zhao^#, Yan Wang^#, Haizhen Long, Dan Liang, Haiyong Zhao, Zengqi Wen, Wei Li, Xia Li, Li Huang, Hongli Feng,Ping Zhu, Ming Li, Qainfei Wang, and Guohong Li*. H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin. Genes & Development, 2013, 27(19):2109-2124. (IF: 10.5)

8.Ping Chen^#, Jicheng Zhao^#, and Guohong Li*. Histone variants in development and diseases. Journal of Genetics & Genomics, 2013, 40(7): 355-365 (IF: 5.9)

9.Jicheng Zhao^#, Langxi Zhang^#, Ye Zhang*, Yufei Shen*. The differential regulation of Gap43 gene in the neuronal differentiation of P19 cells. Journal of Cellular Physiology, 2012, 227(6):2645-2653 (IF: 5.6)

（合作文章：）

10.Cuifeng Liu, Jicheng Zhao, Guohong Li*. Preparation and Characterization of Chromatin Templates for Histone Methylation Assays. Methods Mol Biol, 2022, 2529:91-107.
10. Yuting Liu^#, Kehui Wang^#, Li Huang^#, Jicheng Zhao, Xinpeng Chen, Qiang Wu, Zhouliang Yu, Guohong Li*. Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice. Sci China Life Sci. 2022, 65(9):1881-1889.

11.Kehui Wang^#, Yuting Liu^#, Zhouliang Yu^#, Bo Gu, Jie Hu, Li Huang, Xiao Ge, Lingyi Xu, Mengyu Zhang, Jicheng Zhao, Mingli Hu, Rongrong Le, Qiang Wu, Sheng Ye, Shaorong Gao, Xiaodong Zhang, Rui-Ming Xu, Guohong Li*. Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle. Cell reports, 2021, 37(6):109987.

12.Xueyong Yang^#, Jianbin Yan^#, Zhen Zhang^#, Tao Lin, Tongxu Xin, Bowen Wang, Shenhao Wang, Jicheng Zhao, Zhonghua Zhang, William J Lucas, Guohong Li, Sanwen Huang*. Regulation of plant architecture by a new histone acetyltransferase targeting gene bodies. Nature plants, 2020, 6(7): 809-822

13.Liang Wang^#, Mingli Hu^#, Mei-Qing Zuo, Jicheng Zhao, Di Wu, Li Huang, Yongxin Wen, Yunfan Li, Ping Chen, Xinhua Bao, Meng-Qiu Dong, Guohong Li*, Pilong Li*. Rett syndrome-causing mutations compromise MeCP2-mediated liquid-liquid phase separation of chromatin. Cell research, 2020, 30(5):393-407

14.Xianju Bi, Yanhui Xu, Tong Li, Xinmin Li, Wenzhi Li, Wen Shao, Kaili Wang, Ge Zhan, Zhongyang Wu, Wei Liu, J Yuyang Lu, Liang Wang, Jicheng Zhao, Jiawei Wu, Jie Na, Guohong Li, Pilong Li, Xiaohua Shen*. RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control. Mol Cell. 2019, 75(1):102-116

15.Yan Wang^#, Haizhen Long^#, Juan Yu^#, Liping Dong^#, Michel Wassef, Baowen Zhuo, Xia Li, Jicheng Zhao, Min Wang, Cuifang Liu, Zengqi Wen, Luyuan Chang, Ping Chen, Qian-Fei Wang, Xueqing Xu, Raphael Margueron*, Guohong Li*. Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells. BMC. Biol, 2018, 16(1):107. doi: 10.1186/s12915-018-0568-6.

16.Huanhuan Li^#, Ping Lai^#, Jinping Jia^#, Yawei Song, Qing Xia, Kaimeng Huang, Na He, Wangfang Ping, Jiayu Chen, Zhongzhou Yang, Jiao Li, Mingze Yao, Xiaotao Dong, Jicheng Zhao, Chunhui Hou, Miguel A Esteban, Shaorong Gao, Duanqing Pei, Andrew P Hutchins, Hongjie Yao*. RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions. Cell Stem Cell, 2017, 20(4):462-477.